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We further demonstrated that Dlgap5 overexpression promoted NLRP3/CASPASE1 activation and GSDMD cleavage and pyroptosis, while these effects were abolished by the NF-B inhibitor Bay117082 treatment (Figure 5K), establishing that DLGAP5 initiated NLRP3 inflammasome activation via NF-B pathway

Cell lines Mouse embryonic fibroblasts (MEFs) and their variants (gift of Dr

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Taking a closer look at the cholesterol concentration ( Supplementary Table 5 ), it maintained the initial level until 72 h pi , before reaching a significantly lower level from d 7 pi until the end of the study